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Agrimol B sensitizes PDAC cells to first-line chemotherapy drugs. (A) Schematic overview of PDAC PDO establishment and drug assessment. (B, C) Brightfield images of organoids treated with the indicated concentrations of Agrimol B. Scale bars, 10 μm. (D) Chemical structures of nab-paclitaxel (Paclitaxel), irinotecan, <t>5-fluorouracil,</t> oxaliplatin, and gemcitabine. (E–H) Brightfield images of organoids treated with or without Agrimol B in the presence or absence of nab-paclitaxel, irinotecan, 5-fluorouracil, oxaliplatin, or gemcitabine. Scale bars, 10 μm.
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Agrimol B sensitizes PDAC cells to first-line chemotherapy drugs. (A) Schematic overview of PDAC PDO establishment and drug assessment. (B, C) Brightfield images of organoids treated with the indicated concentrations of Agrimol B. Scale bars, 10 μm. (D) Chemical structures of nab-paclitaxel (Paclitaxel), irinotecan, <t>5-fluorouracil,</t> oxaliplatin, and gemcitabine. (E–H) Brightfield images of organoids treated with or without Agrimol B in the presence or absence of nab-paclitaxel, irinotecan, 5-fluorouracil, oxaliplatin, or gemcitabine. Scale bars, 10 μm.
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Agrimol B sensitizes PDAC cells to first-line chemotherapy drugs. (A) Schematic overview of PDAC PDO establishment and drug assessment. (B, C) Brightfield images of organoids treated with the indicated concentrations of Agrimol B. Scale bars, 10 μm. (D) Chemical structures of nab-paclitaxel (Paclitaxel), irinotecan, <t>5-fluorouracil,</t> oxaliplatin, and gemcitabine. (E–H) Brightfield images of organoids treated with or without Agrimol B in the presence or absence of nab-paclitaxel, irinotecan, 5-fluorouracil, oxaliplatin, or gemcitabine. Scale bars, 10 μm.
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Agrimol B sensitizes PDAC cells to first-line chemotherapy drugs. (A) Schematic overview of PDAC PDO establishment and drug assessment. (B, C) Brightfield images of organoids treated with the indicated concentrations of Agrimol B. Scale bars, 10 μm. (D) Chemical structures of nab-paclitaxel (Paclitaxel), irinotecan, 5-fluorouracil, oxaliplatin, and gemcitabine. (E–H) Brightfield images of organoids treated with or without Agrimol B in the presence or absence of nab-paclitaxel, irinotecan, 5-fluorouracil, oxaliplatin, or gemcitabine. Scale bars, 10 μm.

Journal: Precision Clinical Medicine

Article Title: Agrimol B inhibits pancreatic ductal adenocarcinoma by induction of lethal mitophagy through decreasing mitochondrial transcription termination factor 3

doi: 10.1093/pcmedi/pbag009

Figure Lengend Snippet: Agrimol B sensitizes PDAC cells to first-line chemotherapy drugs. (A) Schematic overview of PDAC PDO establishment and drug assessment. (B, C) Brightfield images of organoids treated with the indicated concentrations of Agrimol B. Scale bars, 10 μm. (D) Chemical structures of nab-paclitaxel (Paclitaxel), irinotecan, 5-fluorouracil, oxaliplatin, and gemcitabine. (E–H) Brightfield images of organoids treated with or without Agrimol B in the presence or absence of nab-paclitaxel, irinotecan, 5-fluorouracil, oxaliplatin, or gemcitabine. Scale bars, 10 μm.

Article Snippet: Hydroxychloroquine (HCQ) (HY-W031727), wortmannin (WORT) (HY-10197), Mdivi-1 (HY-15886), N-acetylcysteine (HY-B0215), Nab-Paclitaxel (HY-P99974), irinotecan (HY-16562), 5-fluorouracil (5-FU) (HY-107856), and oxaliplatin (HY-17371) were purchased from MedChem Express.

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